Bioinformatics Lab

Bioinformatics Laboratory for Precision Medicine

RECENT HIGHLIGHTS

Lung Research
A unified single-cell atlas of human lung provides insights into pulmonary diseases
Largest single-cell atlas for human lung: A unified single-cell atlas of human lung provides insights into pulmonary diseases
eBioMedicine (10. 2025) DOI >
Visual Perception Research
Reconstructing high-resolution visual perceptual images from human intracranial electrocorticography signals
Decoding visual information by brain activity signals provides a window into understanding visual perception and underlying neural mechanism (Peelen and Downing 2023, Shoham et al 2024).
J Neural Eng (9. 2025) DOI >
AI Metabolic Profiling
AI-Driven Disease-Specific Metabolic Profiling:
An end-to-end deep learning method for mass spectrometry data analysis to reveal disease-specific metabolic profiles
Nature Communications (2024) DOI >
AI Embryo Assessment
AI for vitro fertilization Embryo Assessment:
A clinical consensus-compliant deep learning approach to quantitatively evaluate human in vitro fertilization early embryonic development with optical microscope images
AI in Medicine (2024) DOI >
Immunosuppressive Research
Immunosuppressive Class in LUSC and ICB Resistance:
Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance
Genome Medicine (2022) DOI >
AI Lung Cancer Classification
AI for Lung Cancer and Mimic Classification:
Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study
BMC Medicine (2021) DOI >

Bioinformatics Platforms

Precision Medicine Platform

PRECISION MEDICINE Big Data Analysis Community Platform
Biomedical Data Analysis Platform

Biomedical Data Analysis Platform

Bioinformatics Databases

uniLUNG Database

uniLUNG
MicroPhenodb Database

MicroPhenodb
scMoresDB Database

scMoresDB
scMeyesDB Database

scMeyesDB

Grants

博士后招聘(长期有效):
本实验室招聘面向精准医学的生物信息学和医学人工智能的博士后，待遇从优。有意者请直接联系李伟忠教授。(点击查看详情)

Intellectual Properties

欢迎对以下知识产权的转化合作

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Recent Publications

   Wu F, Cai W, Tang H, Zheng S, Zhang H, Chen Y, Han Y, Zhou D, Wang R, Ye M, You R, Chen A, Li J, Zhang X, Li W. A unified single-cell atlas of human lung provides insights into pulmonary diseases. EBioMedicine. 2025 Nov 13;122:106025. doi: 10.1016/j.ebiom.2025.106025. PMID: 41237668.
   Deng Y, Wu X, Gao X, Li W, Zhang D. Reconstructing high-resolution visual perceptual images from human intracranial electrocorticography signals. J Neural Eng. 2025 Sep 5;22(5). doi: 10.1088/1741-2552/ae0070. PMID: 40876481.
   Deng Y, Yao Y, Wang Y, Yu T, Cai W, Zhou D, Yin F, Liu W, Liu Y, Xie C, Guan J, Hu Y, Huang P, Li W. An end-to-end deep learning method for mass spectrometry data analysis to reveal disease-specific metabolic profiles. Nat Commun. 2024 Aug 20;15(1):7136. doi: 10.1038/s41467-024-51433-3.
   Kang Chen, Yutong Han, Yanni Wang, Dingli Zhou, Fanjie Wu, Wenhao Cai, Shikang Zheng, Qinyuan Xiao, Haiyue Zhang, Weizhong Li, scMoresDB: a comprehensive database of single-cell multi-omics data for human respiratory system, iScience, 2024, 109567, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2024.109567.
   Liao Z, Yan C, Wang J, Zhang N, Yang H, Lin C, et al. A clinical consensus-compliant deep learning approach to quantitatively evaluate human in vitro fertilization early embryonic development with optical microscope images. Artificial Intelligence in Medicine. 2024;149:102773.
   Wu F, Lin C, Han Y, Zhou D, Chen K, Yang M, Xiao Q, Zhang H, Li W. Multi-omic analysis characterizes molecular susceptibility of receptors to SARS-CoV-2 spike protein. Comput Struct Biotechnol J. 2023 Nov 10;21:5583-5600. doi: 10.1016/j.csbj.2023.11.012.
   Weizhong Li , Chaoyu Yan, GLUE multimodal single cell data, Precision Clinical Medicine, Volume 6, Issue 1, March 2023, pbad007,https://doi.org/10.1093/pcmedi/pbad007
   Yang M, Lin C, Wang Y, Chen K, Zhang H, Li W. Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance. Genome Med. 2022 Jul 8;14(1):72. doi: 10.1186/s13073-022-01079-x.