李伟忠实验室

Bioinformatics Laboratory for Precision Medicine

RECENT HIGHLIGHTS

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AI-Driven Disease-Specific Metabolic Profiling:
An end-to-end deep learning method for mass spectrometry data analysis to reveal disease-specific metabolic profiles
Nature Communications (2024) DOI >
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AI for vitro fertilization Embryo Assessment:
A clinical consensus-compliant deep learning approach to quantitatively evaluate human in vitro fertilization early embryonic development with optical microscope images
AI in Medicine (2024) DOI >
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Immunosuppressive Class in LUSC and ICB Resistance:
Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance
Genome Medicine (2022) DOI >
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AI for Lung Cancer and Mimic Classification:
Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study
BMC Medicine (2021) DOI >
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Single-Cell Multi-Omics for Respiratory Disease:
scMoresDB: A comprehensive database of single-cell multi-omics data for human respiratory system
iScience (2024) DOI >
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Multi-Omics Analysis of Receptor Susceptibility to SARS-CoV-2:
Multi-omic analysis characterizes molecular susceptibility of receptors to SARS-CoV-2 spike protein
CSBJ (2023) DOI >

Bioinformatics Platforms

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PRECISION MEDICINE Big Data Analysis Community Platform
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Biomedical Data Analysis Platform
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PSISearch2D

Bioinformatics databases

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uniLUNG
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MicroPhenodb
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scMoresDB
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scMeyesDB

Grants

博士后招聘(长期有效):
本实验室招聘面向精准医学的生物信息学和医学人工智能的博士后，待遇从优。有意者请直接联系李伟忠教授。(点击查看详情)

Intellectual Properties

欢迎对以下知识产权的转化合作

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Recent Publications

   Deng Y, Yao Y, Wang Y, Yu T, Cai W, Zhou D, Yin F, Liu W, Liu Y, Xie C, Guan J, Hu Y, Huang P, Li W. An end-to-end deep learning method for mass spectrometry data analysis to reveal disease-specific metabolic profiles. Nat Commun. 2024 Aug 20;15(1):7136. doi: 10.1038/s41467-024-51433-3.
   Kang Chen, Yutong Han, Yanni Wang, Dingli Zhou, Fanjie Wu, Wenhao Cai, Shikang Zheng, Qinyuan Xiao, Haiyue Zhang, Weizhong Li, scMoresDB: a comprehensive database of single-cell multi-omics data for human respiratory system, iScience, 2024, 109567, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2024.109567.
   Liao Z, Yan C, Wang J, Zhang N, Yang H, Lin C, et al. A clinical consensus-compliant deep learning approach to quantitatively evaluate human in vitro fertilization early embryonic development with optical microscope images. Artificial Intelligence in Medicine. 2024;149:102773.
   Wu F, Lin C, Han Y, Zhou D, Chen K, Yang M, Xiao Q, Zhang H, Li W. Multi-omic analysis characterizes molecular susceptibility of receptors to SARS-CoV-2 spike protein. Comput Struct Biotechnol J. 2023 Nov 10;21:5583-5600. doi: 10.1016/j.csbj.2023.11.012. PMID: 38034398; PMCID: PMC10681948.
   Weizhong Li , Chaoyu Yan, GLUE multimodal single cell data, Precision Clinical Medicine, Volume 6, Issue 1, March 2023, pbad007,https://doi.org/10.1093/pcmedi/pbad007
   Yang M, Lin C, Wang Y, Chen K, Zhang H, Li W. Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance. Genome Med. 2022 Jul 8;14(1):72. doi: 10.1186/s13073-022-01079-x. PMID: 35799269; PMCID: PMC9264601.
   Yang M, Lin C, Wang Y, Chen K, Han Y, Zhang H, Li W. Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis. Precis Clin Med. 2022 May 23;5(2):pbac014. doi: 10.1093/pcmedi/pbac014. PMID: 35694714; PMCID: PMC9172646.
   Chen Y, Yang H, Cheng Z, Chen L, Peng S, Wang J, Yang M, Lin C, Chen Y, Wang Y, Huang L, Chen Y, Li W, Ke Z. A whole-slide image (WSI)-based immunohistochemical feature prediction system improves the subtyping of lung cancer. Lung Cancer. 2022 Jan 10;165:18-27. doi: 10.1016/j.lungcan.2022.01.005. Epub ahead of print. PMID: 35065344.
   Yang H, Chen L, Cheng Z, Yang M, Wang J, Lin C, Wang Y, Huang L, Chen Y, Peng S, Ke Z, Li W. Deep learning-based six-type classifier for lung cancer and mimics from histopathological whole slide images: a retrospective study. BMC Med. 2021 Mar 29;19(1):80. doi: 10.1186/s12916-021-01953-2. PMID: 33775248; PMCID: PMC8006383.
   Zhang W, Zeng B, Lin H, Guan W, Mo J, Wu S, Wei Y, Zhang Q, Yu D, Li W, Chan GC. CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects. Oncoimmunology. 2021 Jul 16;10(1):1944553. doi: 10.1080/2162402X.2021.1944553. PMID: 34345532; PMCID: PMC8288037.
   Yao G, Zhang W, Yang M, Yang H, Wang J, Zhang H, Wei L, Xie Z, Li W. MicroPhenoDB Associates Metagenomic Data with Pathogenic Microbes, Microbial Core Genes, and Human Disease Phenotypes. Genomics Proteomics Bioinformatics. 2020 Dec;18(6):760-772. doi: 10.1016/j.gpb.2020.11.001. Epub 2021 Jan 6. PMID: 33418085; PMCID: PMC8377004.
   Zhang W, Zeng B, Yang M, Yang H, Wang J, Deng Y, Zhang H, Yao G, Wu S, Li W. ncRNAVar: A Manually Curated Database for Identification of Noncoding RNA Variants Associated with Human Diseases. J Mol Biol. 2021 May 28;433(11):166727. doi: 10.1016/j.jmb.2020.166727. Epub 2020 Dec 1. PMID: 33275967.
   Zhang W, Yao G, Wang J, Yang M, Wang J, Zhang H, Li W. ncRPheno: a comprehensive database platform for identification and validation of disease related noncoding RNAs. RNA Biol. 2020 Jul;17(7):943-955. doi: 10.1080/15476286.2020.1737441. Epub 2020 Mar 26. PMID: 32122231; PMCID: PMC7549653.
   Yang M, Zhang W, Yao G, Zhang H, Li W. Combined alignments of sequences and domains characterize unknown proteins with remotely related protein search PSISearch2D. Database (Oxford). 2019 Jan 1;2019:baz092. doi: 10.1093/database/baz092. PMID: 31317184; PMCID: PMC6637259.

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